Title - EMG Controlled BOT

Abstract - Textile industry is one of the most imperative industries in India and is also one of the major consumers of water (Average Consumption - 14 lakh liters per day). Treatment of this water is of utmost importance to maintain ecological balance. Textile wastewater is a mixture of effluents from various processes. In addition to this, the Central Government, on 22nd October 2015, has drafted a notification that has directed every large scale textile industry to strictly follow ZLD norms. Thus, keen focus has been laid on transforming each textile unit into an ideal yet economical ZLD. This project is an attempt to transform this indigenous industry in India to an ideal yet economical Zero Liquid Discharge (ZLD) using basic fundamentals of engineering, management and natural sciences.

Title - Microchips for Drug Delivery

Abstract - Drug therapies are very efficient and effective in treating life threatening diseases. Many of the traditional routes of administration of the drug, such as intravenous infusion or oral capsules, faces problems of maintaining drug concentrations , sustained release rate, targeting at a specific sit and pulsatile delivery at variable intervals of time. As a result, a new class of controlled-release of drug delivery system of smart, programmable microelectronics devices called as microchips was developed. Microchips is a device which controls both rate and time release of drug. They are capable of producing simultaneous constant and pulsatile delivery, complex release patterns of drug delivery, increased accuracy, and isolation of the drug from the outside environment. Moreover, their small size, potential for integration with microelectronics, and ability to store and release chemicals on demand with the help of reservoirs could make controlled-release microchips useful in a number of applications like medical diagnostics, analytical chemistry, chemical detection, industrial process monitoring and control, combinatorial chemistry, microbiology, and may provide new treatment options to clinicians in their fight against disease.

Title - Nano Technology for Drug Delivery System

Abstract - Materials derived from Nanotechnology bestows unparalleled optical, mechanical and electronic properties which can be used to manufacture high performance light emitting devices, environmental cleaning nanoparticles and drug delivery vehicles. Nanomaterials (i.e nanotubes and nanoscrolls) are providing an explosion of interest with their potential futuristic uses. Nanotubes are hollow cylinders with diameter in few billionth of a meter and length a million times longer whereas Nanoscrolls are structurally different cylinders made from Graphene Oxide (GO) and can be visualized as a GO sheet rolled in within itself into a spiral wound structure. The resultant assembly resembles a scroll of parchment and offers a strikingly different morphology then traditional Carbon based nanotubes. Particularly in the field of medical sciences, nanoparticles (NP) have a potential to have massive impact as drug delivery vehicles for the treatment of various malignant diseases.

Nanoparticle based therapeutics are currently used for the treatment of various deadly diseases including diabetes, cancer, cardiovascular and other gastro-intestinal diseases. However, these therapeutics are administered parenterally thereby limiting their use and application. The current review paper throws light on the fact that these therapeutics can be suitably modified and orally administered, considering the convenience and compliance by the patients. This makes the NP based therapeutic suitable for use in treatment of diseases that demands daily therapy. The nanoparticle is first prepared by biodegradable polymers namely Polylactic acid and polyethylene glycol. These nanoparticles are then conjugated with the drug payload and chemically modified so as to prevent an immunological response from the body. The therapeutic is very specific to target molecules and also protect the drug payload through encapsulation. This biodegradable therapeutic then uses a very specific ‘transcytosis pathway’ to reach the targeted tissues and organs avoiding any deleterious side effects. After complete release of the drug, the drug is cleared from the body without leaving a trace. With scrupulous research in this field, this breakthrough technology can cure many diseases that used to haunt the mankind for ages.

Title - Synthesis and Biological Activity of Novel Hererocyclic Derivatives

Abstract - Research in the field of pharmaceutical has its most important task in the development of new and better drugs and their successful introduction into clinical practice. During the period of 1940 to 1960 a large number of important drugs have been introduced and this period is regarded as "Golden Period" of new drug discovery. The synthesis of heterocycles is of great importance in pharmaceutical and medicinal chemistry. During the past decade, the threat of antimicrobial resistance has become increasingly real and its global dimensions have been increasingly recognized. The nitrogen heterocycles in general and pyrimidines in particular are found in several biologically active natural products and depict considerable therapeutic potential. The present study focus on the synthesis of derivatives like dihydropyrimidines, triazole, pyrimidines etc. and to evaluate them for antimicrobial and antifungal activity.

Compounds ASB1, ASB2, ASB3 and ASB4 were synthesized by conventional method and checked for their antibacterial and antifungal activity. From antimicrobial results compound ASB2 and ASB4 were found to be more potent than Ciprofloxacin. Structure activity relationship it reveals that thiopyrimidine derivatives have good antimicrobial activity. In case of antifungal activity ASB4, ASB2, ASB1 shown promising activity while ASB3 shown equipotent biological activity compared to reference standard fluconazole.